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A |     首席研究员Jonathan Repple教授在维也纳举行的欧洲神经精神药理学学院大会上介绍了这项工作。

B | 他说:“这意味着严重临床抑郁症患者的大脑结构并不像我们想象的那样固定,我们可以在短时间内改善大脑结构,大约6周。

C | 我们发现,如果这种治疗方法能导致大脑连接性的增加,那么它在解决抑郁症症状方面也是有效的。

D | 这给那些认为没有什么可以改变,他们必须永远带着疾病生活的病人带来了希望,因为疾病在他们的大脑中已经 ‘定格’了。    Brussels, Oct 13 (UNI) Ukraine's Nato-led allies have announced deliveries of advanced air defence weapons to Kyiv after a spate of Russian missile strikes.

The weaponry promised by the UK, Canada, France and the Netherlands includes missiles and radars. The US earlier made a similar pledge. One high-tech system from Germany is already in Ukraine, BBC reported.

The pledges come as Ukraine's allies from 50 countries meet at the Nato headquarters in Brussels. Kyiv hailed the summit as "historic", BBC said.

Hours later, Russian shelling hit the southern city of Mykolaiv on Thursday morning.

Monday and Tuesday saw some of the heaviest Russian bombardment in months when more than 100 missiles were launched, hitting energy infrastructure and other non-military targets. At least 19 people were killed on the first day of the strikes, which included hitting central Kyiv.

Russian President Vladimir Putin says the missile strikes were retaliation for an attack on a key bridge linking Russia and Crimea -- Ukraine's southern peninsula annexed by Moscow in 2014.

The UK will donate air defence missiles, as well as hundreds of aerial drones to support Ukraine's information gathering and logistics capabilities. It will also provide 18 howitzer artillery guns in addition to the 64 already delivered.

"Russia's latest indiscriminate strikes on civilian areas in Ukraine warrant further support to those seeking to defend their nation," said British Defence Secretary Ben Wallace.

French President Emmanuel Macron said Paris would supply air defence systems to Ukraine, the BBC reported.

The Netherlands said it would deliver €15m ($14.5m) worth of air defence missiles. Dutch Defence Minister Kajsa Ollongren said the Russian attacks "can only be met with unrelenting support for Ukraine and its people".

Canada pledged to provide more than C$47m ($34m) worth of military aid, including satellite communications and drone cameras.

Ukraine's military announced on Wednesday that the first of several "state-of-the-art IRIS-T SLM has been delivered from Germany to Ukraine". It said the air defence system would help protect the country "against terror".

Russia has repeatedly warned Ukraine's allies against supplying advanced weaponry to Kyiv, stressing this would make them participants of the war that Putin began in February.

UNI MR。”在德国明斯特大学工作的科学家们研究了109名严重抑郁症(重度抑郁症)患者,并将他们与55名健康对照者进行了比较。使用核磁共振扫描仪对参与者的大脑进行了扫描,该扫描仪的设置是为了确定大脑的哪些部分与其他部分进行交流,以此来测量大脑内的连接水平。然后,这些病人接受了抑郁症治疗,一些人接受了电休克疗法(ECT),一些人接受了心理治疗或药物治疗,还有一些人接受了所有疗法的组合。治疗结束后,研究参与者被重新用核磁共振扫描来测量大脑连接的数量。

E | 他们还被重新测试了抑郁症的症状。Repple教授(现为法兰克福大学预测性精神病学教授)说:“我们发现,对抑郁症的治疗改变了大脑的基础设施,这与之前的预期相反。接受治疗的病人显示出比治疗前更多的连接。

F | 此外,那些对治疗表现出最大反应的人比那些表现出很少反应的人发展了更多的新连接。第二次扫描显示在健康对照组中没有时间效应,这支持了我们的发现,即我们看到了与疾病有关的东西,更重要的是这种疾病的治疗。”“我们发现这些变化只发生在6周左右的时间内,我们对反应的速度感到惊讶。我们没有解释这些变化是如何发生的,也没有解释为什么它们会在如此不同的治疗形式下发生。”荷兰奈拉德堡德大学医学中心的Eric Ruhe博士在评论时说:“这是一项非常有趣的、难以执行的研究,作者通过重复核磁共振扫描,揭示了接受抑郁症治疗的患者的结构连接性随时间的变化。”“结果与我们目前的信念非常一致,即大脑在(甚至是短时间)内的适应性比以前认为的要灵活得多。事实上,治疗抑郁症(和其他精神疾病)所引用的一个主要想法是随着时间的推移发生可塑性变化。这已被提议作为抗抑郁药、心理治疗和电休克疗法的一个共同机制。然而,阐明哪些变化是对治疗的反应或抑郁症的缓解所必需或特定的研究数量有限。此外,下一个问题是,不同的治疗方法是否有可能专门改变目标的大脑网络,或者反过来说,我们是否可以利用本研究中测量的大脑网络的干扰来选择哪种疗法会有帮助。

G | ”“观察到的随时间变化不能与某种形式的治疗联系起来,这是一个遗憾,但正如作者自己所建议的,这是一个需要进一步研究的课题。首先,这些结果应该在独立的样本中进行复制,希望这很快就会发生。其次,对这种方法的进一步阐述将是令人生畏的,应该得到坚定的支持,因为这项工作可能有助于弥合目前神经科学和循证病人护理之间的差距。”这是一个独立的评论,Ruhe博士没有参与这项研究。

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